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PEGDA
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| Polyethylene (glycol) diacrylate-based hydrogels are powerful tools for uncovering basic cellular biology because they are considered biologically inert ("blank slate") and their mechanical properties can be varied over a large range of moduli. In addition, PEGDA hydrogels is an emerging scaffold for tissue engineering and Regenerative Medicine since polymerization can occur rapidly at room temperature and requires low energy input, has high water content, is elastic, and can be customized to include a variety of biological molecules. |
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Basic Information
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| Polyethylene (glycol) diacrylate (PEGDA) is a synthetic, hydrophilic starting material which forms hydrogels in the presence of photoinitiator and UV light. PEGDA hydrogels are easily customizable since ECM proteins and/or growth factors can be incorporated into a hydrogel and its stiffness can be modulated from 10-100 kPa (9, 10). PEGDA is widely recognized as a biocompatible, non-immunogenic, and capable of chemical manipulation to incorporate attachment peptides (1, 6), degradable peptides (1,2), and other moieties (3). |
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