PEG Products

Maya Chemical provides high quality PEG products with low polydispersity and low diol content. Functionally, including active PEG derivatives for amine PEGylation, active PEG derivatives for N-terminal PEGylation, and active PEG derivatives for thiol PEGylation. Structurally, including branched PEG derivatives, linear PEG derivatives, homobifunctional PEG Derivatives, heterobifunctional PEG Derivatives, and multi-arm PEG derivatives. PEG derivatives with different functional groups, custom PEG derivatives, and PEG raw materials are also available.

PRODUCTS LIST

PRODUCTS FOR AMINE PEGYLATION ..................... 2

PRODUCTS FOR THIOL PEGYLATION .....................2

PRODUCTS FOR N-TERMINAL

PEGYLATION.....................3

OTHER LINEAR METHOXY PEG DERIVATIVES..................... 3

HOMOBIFUNCTIONAL PEG DERIVATIVES..................... 3

HETEROBIFUNCTIONAL PEG DERIVATIVES .....................4

MULTI-ARM PEG DERIVATIVES..................... 5

LINEAR METHOXY PEG RAW MATERIALS .....................7

MULTI-ARM PEG RAW MATERIALS.....................7

Other molecular weights are available.
Custom synthesis is available.
Quotations for bulk orders are available.
cGMP quality is available.

• To order please contact:
  Maya Chemical Company
• Tel: 02-28586296 Fax: 02-28588517
  Email: michelle@maya-chemical.com

Products for Amine PEGylation

Products for Thiol PEGylation

• To order, please contact us at michelle@maya-chemical.com

Products for N-Terminal PEGylation

Other Linear Methoxy PEG Derivatives

Homobifunctional PEG Derivatives

• To order, please contact us at michelle@maya-chemical.com

Heterobifunctional PEG Derivatives

The NHS esters in this category are all Succinimidyl Carboxymethyl Ester (SCM).

Multi-arm PEG Derivatives
4ARM-PEG Derivatives (pentaerythritol core)

• To order, please contact us at michelle@maya-chemical.com

8ARM-PEG Derivatives (hexaglycerin core)

8ARM-PEG Derivatives (tripentaerythritol core)

• To order, please contact us at michelle@maya-chemical.com

Linear Methoxy PEG Raw Materials

Multi-Arm PEG Raw Materials
4ARM-PEG Raw Materials (pentaerythritol core)

8ARM-PEG Raw Materials (hexaglycerin core)

8ARM-PEG Raw Materials (tripentaerythritol core)

• To order, please contact us at michelle@maya-chemical.com

Branched PEG Derivatives for PEGylation

Branched PEG derivatives, also known as "Y-shaped" PEG derivatives, contain two linear methoxy PEG chain attached to a central core. The sterically bulky structure of these "Y-shaped" PEG derivatives will facilitate the single point attachment of the modified molecules.
The typical structure of "Y-shaped" branched PEG is as the following:

Maya now provides the following three kinds of "Y-shaped" PEG derivatives. Y-NHS-40K is used for amine PEGylation, Y-MAL-40K is used for thiol PEGylation, and Y-ALD-40K is for N-terminal PEGylation.
"Y-shaped" PEG derivatives are chemically purified during synthesis so that they are low in polydispersity and are essentially free of activated bifunctional PEG side products.

For Amine PEGylation

Y-NHS-40K: Y-Shape PEG NHS Ester, MW 40000

This "Y-shape" NHS ester will react with the amino group of lysine(s) or the N-terminal amine in biological active molecules to produce a stable amide linkage(s). This NHS ester will couple with the targeted molecules at pH 7-8. The PEGylation reaction can be finished in about 1 hour.
Average molecular weight of this product is 40,000 Da. Substitution of this product is 95% or greater. This product is basically free of activated bifunctional PEG side products.

For Thiol PEGylation

Y-MAL-40K: Y-Shape PEG Maleimide, MW 40000

This "Y-shape" maleimide will react with the thiol groups in biological active molecules to generates a stable 3-thiosuccinimidyl ether linkage. This maleimide will couple with the targeted molecules at pH 5.0-6.5 in the presence of other functional groups.
Average molecular weight of this product is 40,000 Da. Substitution of this product is 90% or greater. This product is basically free of activated bifunctional PEG side products.

For N-Terminal PEGylation

Y-ALD-40K: Y-Shape PEG Aldehyde, MW 40000

This "Y-shape" aldehyde will preferably react with the N-terminal amine in biological active molecules to produce a stable amine linkage in the presence of a reducing reagent such as sodium cyanoborohydride. This aldehyde will couple with the N-terminal amine of the targeted molecules at pH 5-8.
Average molecular weight of this product is 40,000 Da. Substitution of this product is 90% or greater. This product is basically free of activated bifunctional PEG side products.

To order, please contact us at michelle@maya-chemical.com.

PEG Derivatives Custom Synthesis

Branched PEG derivatives, also known as "Y-shaped" PEG derivatives, contain two linear methoxy PEG chain attached to a central core. The sterically bulky structure of these "Y-shaped" PEG derivatives will facilitate the single point attachment of the modified molecules. Maya provides branched PEG derivatives for amine pegylatin, thiol pegylation, and N-terminus PEGylation. JenKem's regular branched PEG products include:

Y-NHS-40K, Y-shape PEG NHS Ester, MW 40000

Y-MAL-40K, Y-shape PEG Maleimide, MW 40000

Y-ALD-40K, Y-shape PEG Aldehyde, MW 40000

Linear Monofunctional PEG Derivatives For PEGylation

Linear monofunctional PEG derivatives have a reactive group at one end of the PEG and the other end is capped with a methoxy group or a sugar group.

Linear monofunctional PEG derivatives have the following general structure:

CAP-PEG - X

where X is the functional group or active group and CAP can be either a methoxy group or a sugar molecule

Two patented high molecular weight linear monofunctional PEG derivatives, GLUC-NHS-35K and GALA-NHS-35Kare provided. They are both used for amine PEGylation.

For Amine PEGylation

The following linear PEG NHS esters as regular products meet with your different PEGylation requirements. Other PEG NHS esters with different molecular weights are available through custom synthesis.

GLUC-NHS-35K: Glucose PEG NHS Ester, MW 35000

This N-hydroxysuccinimide (or NHS) ester will react with the amino group of lysine(s) or the N-terminal amine in biological active molecules to produce a stable amide linkage(s). The presence of glucose group will increase the selectivity of the PEGylation reaction. GLUC-NHS-35K will couple to the targeted molecules at pH 7-8. The PEGylation reaction can be finished in about 1 hour.

The average molecular weight of GLUC-NHS-35K is 35,000 Da. Substitution is 90% or greater. This product is basically free of active difunctional PEG impurities.

GALA-NHS-35K: Glucose PEG NHS Ester, MW 35000

This N-hydroxysuccinimide (or NHS) ester will react with the amino group of lysine(s) or the N-terminal amine in biological active molecules to produce a stable amide linkage(s). The presence of galactose group will increase the selectivity of the PEGylation reaction.
GALA-NHS-35K will couple with the targeted molecules at pH 7-8. The PEGylation reaction can be finished in about 1 hour.

The average molecular weight of GALA-NHS-35K is 35,000 Da. Substitution is 90% or greater. This product is basically free of active difunctional PEG impurities.

M-PEG-SCM: Methoxy PEG Succinimidyl Carboxymethyl Ester, MW 2000, MW 5000, MW 20000, MW 30000, MW 35000, MW 40000

This N-hydroxysuccinimide (or NHS) ester will react with the amino group of lysine(s) or the N-terminal amine in biological active molecules to produce a stable amide linkage(s). This NHS ester will couple with the targeted molecules at pH 7-8. The PEGylation reaction can be finished in about 1 hour. Substitution of M-SCM-20K is 95% or greater. M-PEG-SCM is basically free of active difunctional PEG impurities.

For Thiol PEGylation

M-PEG-MAL: Methoxy PEG Maleimide, MW 2000, MW 5000, MW 20000, MW 30000, MW 40000

M-PEG-MAL reacts with the thiol groups on cystein side chains in proteins and peptides to generates a stable 3-thiosuccinimidyl ether linkage. This maleimide will couple with the targeted molecules at about pH 5.0-6.5 in the presence of other functional groups. Substitution of M-PEG-MAL is 90% or greater.

M-PEG-VS: Methoxy PEG Vinylsulfone, MW 5000, MW 20000

Sulfhydryl additon to the vinylsulfone generates a stabel beta-thiosulfonyl linkage. Vinylsulfone is stable in aqueous solution for a long time at high pH. Substitution of M-PEG-VS is 90% or greater. Purity of M-VS-PEG is 95% or greater.

M-PEG-SH: Methoxy PEG Thiol, MW 5000, MW 20000

M-PEG-SH reacts with the thiol groups on cystein side chains in proteins and peptides to generates a disulfide-bridged polymer conjugate. Substitution of M-PEG-SH is 90% or greater. Purity of M-SH-PEG is 90% or greater.

For N-Terminal PEGylation

M-PEG-SH: Methoxy PEG Thiol, MW 5000, MW 20000

M-PEG-ALD preferably reacts with the N-terminal amine in biological active molecules to produce a stable amine linkage in the presence of a reducing reagent such as sodium cyanoborohydride. This aldehyde will couple with the N-terminal amine of the targeted molecules at pH 5-8. Substitution of M-PEG-ALD is 95% or greater. Purity of M-PEG-ALD is 95% or greater.

Other Linear Methoxy PEG Derivative

M-NH2-PEG: Methoxy PEG Amine, HCl Salt, MW 2000, MW 5000, MW 20000, MW 30,000, MW 40,000

Substitution of M-NH2-20K is 95% or greater. The HCl Salt form provides stability in the solid form.

M-HZ-PEG: Methoxy PEG Hydrazide, MW 5000, MW 20000

To order, please contact us at michelle@maya-chemical.com

Other moleculars weights are available.
Quotations for bulk orders are available.